"I am not your enemy Guybrush. In fact, I have most likely saved you from yourself." - The Voodoo Lady voices her true nature and allegiance to Guybrush

The Voodoo Lady is a recurring side-character who often gives advice to Guybrush Threepwood, known as a nameless voodoo priestess, who keeps a careful watch over the seas for those who would misuse the powers of voodoo for sinister purposes, specifically the demon pirate, LeChuck, and his sinister cohorts. Her importance in the first game is somewhat fleeting as the game can be completed without talking to her, but in all her subsequent appearances she plays a key role to the player's progress. While she aids Guybrush numerous times throughout the series, her true allegiance and nature becomes much more clouded and sinister as the series progresses, eventually revealing the Voodoo Lady as a keen manipulator who exploits and even indirectly causes many of the events over the course of the series through her ambiguous guidance for her own agenda.

The exact contents of such an agenda are unclear, though she urges Guybrush to believe that she has always had his best interests at heart and seemed to genuinely value his heroism in taking down LeChuck, a man who she claims was always doomed to have a villainous life and destiny. While it is known that she has helped both Guybrush and LeChuck in various ways, it is made clear that she sees LeChuck as a true abomination who exploits the powers of voodoo for destruction and his own insidious purposes without following the natural state of order and must be taken down for the good of the Caribbean and beyond. Guiding the fates of Guybrush, Elaine Marley, and LeChuck, the Voodoo Lady is keen to ensure that certain events throughout the Seven Seas follow a specific path for an unknown goal. Her clouded nature, past, and agenda have served as one of the series' most pivotal and elaborate plot points throughout the games with varying levels of importance towards each game's plot.