One of 5 founding members of the Avengers in 1963 (Avengers #1), not only did "The Wasp" come up with the name for the faction, becomes the leader in the 1980's after she divorces then paranoid, overbearing and verbally abusive Ant-Man who had concocted a plan to make himself look good in front of the Avengers by staging an attack that can only he could stop.

Of course rather that being allowed to be the leader she is given the designation of "Chairperson". After handing off the leadership to Vision, she becomes the leader again, before handing over to Cpt America in the Secret War storyline, before being captured by Magneto, eventually outsmarting and defeating him single handedly leaving the rest of the Avengers to do cleanup.

During the Under Siege storyline, she becomes the leader for a third time, this time eventually handing over to Captain Marvel.

She then joins the West Coast Avengers as a reserve member. Although only being a reserve she still manages to become their leader.

During Destiny War in the 90's she becomes the leader for a 5th time, and then for a 6th time in the 2000's, before reconciling with her ex-husband Ant Man on 2005, after Avengers Disassembled. Although reconciled, she refuses to re-marry him.

In Mighty Avengers, Ant Man gives The Wasp a refined growth formula which allows her to shift to giant-size without side effects. Eventually, she realises that her husband is an undercover Skrull, and the serum she was given has turned her into a bio-bomb. After leaving the battlefield, and drawing as many Skrulls to her as she can, she explodes. Afterwards, Ant-Man starts wearing he suit. Yeah, it got weird. Right there.